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Clinical Trial for Kisspeptin Test in London.

November 25, 2018
A clinical trial in London for Kisspeptin test.
Kallman’s syndrome / Congenital Hypogonadotropic Hypogonadism (CHH) is a condition that is frequently due to a problem with the function of an important part of the brain called the ‘hypothalamus’.
Kisspeptin is a naturally occurring hormone (already present in the body) that was discovered in 2003 and is known to be able to be able to safely stimulate the hypothalamus.
Kisspeptin has been given at our centre in Imperial College London to several hundred men and women and has not been associated with any side effects to date.
We are looking to better understand how useful a ‘kisspeptin test’ could be to identify patients with CHH and whether their ability to respond to kisspeptin could provide useful information about the current function of their hypothalamus (for example, patients with CHH can sometimes spontaneously normalise their hypothalamic function, which could be identified through a kisspeptin test).
The current research study would involve 2 visits (each lasting up to 7hrs in total starting in the morning) occurring at least one week apart at Charing Cross Hospital in Hammersmith, London.
Following an explanation of the study and a review of clinical details and examination, potential participants can indicate their willingness to take part in the research by signing a research consent form.
All research ethical practice such as confidentiality will be respected throughout.
One visit will be to have a ‘kisspeptin test’ and the other will be to have the currently used test called a ‘GnRH test’.
At each visit, a cannula (plastic tube) would be placed in a vein in the arm to allow us to give the GnRH or kisspeptin hormones and then to take blood without requiring any further needles.
We would not expect participants to encounter any adverse effects during or after either visit in either the short or long term.
A blood sample will also be taken to screen for genes involved in the function of the hypothalamus.
A formal smelling test will be performed to record whether the sense of smell is intact.
Participants can eat and drink as usual and are encouraged to bring food/entertainment (wifi will be made available).
Participants will be reimbursed £100 for each visit for their time in addition to travel expenses.
If travelling from outside of London, we will also arrange accommodation if needed.
If you would like to learn more about this research, you can email us at
and leave your contact number and we will be pleased to get in touch with more information.
One Comment
  1. I attended the screening test for this trial today at Charing Cross Hospital in London.

    I had a very comprehensive health check. I am now hoping to attend 2 clinic days for the testing.

    They will pay people to attend the 2 days of clinic testing with accommodation and travel to London. They are happy to hear from anybody in the UK who would like to take part.

    Part of the study with involve genetic screening undertaken bt the research lab in Switzerland. They told me they are happy to share the results of the genetic testing with each patient should they want to know their results.

    Part of the study is to see how different people with Kallmann syndrome / CHH respond to treatment with a drug called Kisspeptin. The idea is that Kisspeptin could be used as a diagnostic test to distinguish Kallmann syndrome from delayed puberty at an earlier age.

    They were very friendly and helpful today. They would like to hear from anybody who would like more information or who wishes to take part.

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