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Kallmann Syndrome & Osteoporosis

January 31, 2011

One side effect of undiagnosed or untreated  Kallmann syndrome is the increased risk of developing osteoporosis (brittle bones).

Testosterone in men and oestrogen in women is vital to keep the bones strong and low levels of these two hormones can lead to an increased risk of fractures at any stage in life. Some patients with Kallmann syndrome can develop osteoporosis at a very early age.

People with Kallmann syndrome or hypogonadotrophic hypogonadism should be getting a bone density scan (DEXA scan) once every 5 years at the very least, even if they are on hormone replacement therapy. The DEXA scan is a very quick and simple test in which an enhanced x-ray is taken of the hips & spine to judge the density & strength of the bones.

Those found to have weaker bones than normal for their age can be prescribed extra medication in order to help them strengthen their bones and more regular DEXA scans are required if a previously abnormal result is found.

The use of Vitamin D supplements in the diet is now thought to be of greater benefit for bone strength and overall general health instead of taking calcium supplements only.

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